Quadrupole mass spectrometer MS-1 for chemical analysis of the ionosphere The principle of operation, as well as the features and advantages of the MS-1 mass spectrometer installed on board the MN-300 rocket are described. The device is designed to determine the elemental, molecular and ionic composition of the ionosphere, as well as to study the kinetics of various processes. The main technical characteristics are given.
Quantitative determination of immunosuppressants in whole blood by tandem liquid mass spectrometry Shimadzu offers a hardware complex for highly sensitive quantitative determination of immunosuppressants in whole blood by tandem liquid mass spectrometry with fully automated sample preparation and using high-quality 13C-standards. Application examples are described, the results confirm the high accuracy, sensitivity and selectivity of the new analysis technique.
Design of antibacterial and antituberculosis agents: general Ser/Thr pharmacophore approach application Based on suggested earlier general Ser/Thr pharmacophore approach two series of compounds were designed and synthesized as possible inhibitors of bacterial serine/threonine kinases. These compounds showed promising activity in cell based assays against virulent H37Rv (MIC 1–10 µM) and S.Aureus (MIC 4–16 µg/ml).
Cryo-electron microscopy is a revolutionary method for determining the structure of biological molecules The principles and advances of cryo-electron microscopy are described; the method is the most powerful tool that allows visualizing of biological objects during their functioning, which is invaluable both for a basic understanding of life chemistry and for a wide range of applied problems. For the development of the cryo-electron microscopy Jacques Dubochet (Switzerland), Joachim Frank (USA) and Richard Henderson (United Kingdom) were awarded the Nobel Prize in Chemistry in 2017.
Rapid screening of medicines without using standard samples: renaissance of low-field NMR spectrometers The use of modern low-field 1H NMR spectrometers at a working frequency of 60 MHz is proposed to control the authenticity of medicines. For validation and verification of the developed methods of non-standard screening, the use of a low-field and high-field (more than 300 MHz for 1H) tandem is recommended.
Chromatographic analysis of building materials A brief review of chromatographic methods allowing to determine the presence and content of ecotoxicants and other components in various materials and in air on construction sites is given. The ways of solving problems of analytical quality control and safety of building materials are discussed.
Effect of soils on the corrosion of steel pipes. Modeling stress-corrosion processes To prevent emergencies on pipelines operated 15–20 years or more, it is important to assess their condition in time and in a qualified manner. The results of experimental studies of the characteristics of the pipe steels of main oil pipelines in model aggressive environments are presented, graphical dependencies are constructed, and corrosion-mechanical processes are analyzed.